Remove letters not used in Latin and letters that are used too seldom, such as J W Y K Z.
Current values on the tiles can be maintained, or you can change the values to those suggested below to correspond more readily with a letter's frequency of use in Latin (the less frequently a letter occurs, the higher its point value should be).
Keep a Latin/English dictionary handy for resolving conflicts (I also allow students to look up words if the game is progressing too slowly).
Try different themes. For example, play a game where only verbs can be used or a game with only adjectives.